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doi: 10.1016/j.jaci.2011.02.002 118 ShastriM

Chord-Melody Tension 9 Chord-Melody Tension: Quantifies how often melody notes fall outside the current chord, producing dissonance that creates a sense of instability

Researchers pin the underlying mechanism on THC activating a type of cellular receptor known as transient receptor potential ankyrin type 1 (TRPA-1 for short)